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Richie Wellens makes four changes to the Orient side that lost at home to Stockport a week ago. Tom James, Jack Simpson, Diallang Jaiyesimi and Sonny Perkins replace Brandon Cooper, Darren Pratley, Azeem Abdulai and Dilan Markanday.
With Real Madrid waiting on Tuesday, Pep Guardiola has made nine changes from the defeat at Arsenal. The survivors are Stefan Ortega and Omar Marmoush. The new signings Vitor Reis and Nico Gonzalez make their City debuts.